
Trametenolic acid
CAS No. 24160-36-9
Trametenolic acid ( —— )
产品货号. M31264 CAS No. 24160-36-9
Trametenolic acid is a cytotoxic agent.It exhibits a mode of mixed inhibition with a K I of 0.9μM, K IS of 0.5μM, and an IC50 of 7.25μM.
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
10MG | ¥2886 | 有现货 |
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50MG | 获取报价 | 有现货 |
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100MG | 获取报价 | 有现货 |
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生物学信息
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产品名称Trametenolic acid
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述Trametenolic acid is a cytotoxic agent.It exhibits a mode of mixed inhibition with a K I of 0.9μM, K IS of 0.5μM, and an IC50 of 7.25μM.
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产品描述Trametenolic acid is a cytotoxic agent.It exhibits a mode of mixed inhibition with a K I of 0.9μM, K IS of 0.5μM, and an IC50 of 7.25μM.Trametenolic acid and Betulin as a new candidate of potent tyrosinase inhibitors, can decrease tyrosinase activity and melanin content.
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体外实验Trametenolic acid (1 mg/mL; 15-30 mins) induces the upregulation of autophagy-related proteins (Beclin-1, Atg12, and LC3) in B16-F1 cells by activating the ERK1/2 signaling pathway.Trametenolic acid (1 mg/mL; 24 hours; B16-F1 cells) has dual synergic mechanisms to exert an anti-melanogenetic effect.Trametenolic acid (0.1-4 mg/mL; 52 hours; B16-F1 cells) increase melanin synthesis by approximately 20% and 40% in cells transfected with siRNAs against mTOR and Atg5, respectively. Western Blot Analysis Cell Line:B16-F1 cells Concentration:1 mg/mL Incubation Time:15 and 30 mins Result:Increased the expression levels of phospho-p38, phospho-ERK1/2, Beclin-1, Atg12 and LC3 by approximately 46%, 10%, 48%, 126% and 49%, respectively.Western Blot Analysis Cell Line:B16-F1 cells Concentration:1 mg/mL Incubation Time:24 hours Result:Increased the expression of ERK1/2 and p-ERK1/2 and decreased MITF, tyrosinase, and TRP 1 levels.
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体内实验——
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同义词——
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通路Others
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靶点Other Targets
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受体——
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研究领域——
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适应症——
化学信息
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CAS Number24160-36-9
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分子量456.7
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分子式C30H48O3
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 50 mg/mL (109.48 mM)
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SMILES——
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
产品手册




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